Description
Poliovirus receptor-related 3 (PVRL3), also known as nectin-3 and CD113, is a human protein of the immunoglobulin superfamily which forms part of adherens junctions.
Nectins are immunoglobulin-like adhesion molecules that interact with afadin (AF6; MIM 159559).
Afadin is an actin filament-binding protein that connects nectins to the actin cytoskeleton.
The nectin-afadin system organizes adherens junctions cooperatively with the cadherin system in epithelial cells.
PVRL3 plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions.
Furthermore, PVRL3 induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation